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It was discovered that naltrexone and bupropion combined, which may be marketed later on as Contrave, provide better weight loss results than dieting and exercise alone.

Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err to the side of caution and let the FDA do its job and demand some investigation be done so the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to make money and that they would say almost anything to keep people on their own medications.

Researchers found out that participants taking this drug for the year, dropped a few pounds within 4 weeks and have kept the extra weight off through the 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which can make them more efficient and safer.

Combo-pilling may be the newest fad or in addition to this the newest in the future under scrutiny and thus it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is now popular may be the fact that by right now there aren't any long term prescription diet pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug also can raise blood pressure and heartbeat, and must not be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heartbeat and must 't be used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.


Approving a drug using this type of many potentially lethal side effects is inconsistent while using mission statement of the FDA. The power with the drug manufacturing lobby is blatantly evident inside approval of countless drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside US.

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